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Symbol
Name
ID

Ptgs2
prostaglandin-endoperoxide synthase 2
MGI:97798

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Facial palsy	Increased CSF protein concentration	Anorexia	Abnormal cerebrospinal fluid morphology	Depression	Anxiety	Peripheral neuropathy
Disease(s) Associated with PTGS2	Facial palsy	Increased CSF protein concentration	Anorexia	Abnormal cerebrospinal fluid morphology	Depression	Anxiety	Peripheral neuropathy
cystic fibrosis
pancreatic cancer
sarcoidosis

Mouse Phenotypes		increased susceptibility to pharmacologically induced seizures	tonic-clonic seizures	decreased susceptibility to neuronal excitotoxicity	increased susceptibility to neuronal excitotoxicity	abnormal response to CNS ischemic injury	decreased cerebral infarct size	abnormal inhibitory postsynaptic currents
Availability	Mouse Genotype		tonic-clonic seizures	decreased susceptibility to neuronal excitotoxicity	increased susceptibility to neuronal excitotoxicity	abnormal response to CNS ischemic injury	decreased cerebral infarct size	abnormal inhibitory postsynaptic currents
	Ptgs2^tm1Unc/Ptgs2^tm1Unc
	Ptgs2^tm1Unc/Ptgs2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23